In the chronic digestive form of the disease, the clinical manifestations result from dysperistalsis of the esophagus and colon caused by destruction of the myenteric plexuses, which consequently leads to megaesophagus and megacolon. Although isolated cases of autonomic disorders of the esophagus have been described in the acute phase of the disease, these occur mostly in the chronic phase, when the dysperistalsis and spasms are accompanied by enlargement of the esophagus. This picture shows megacolon. Enormous megacolon in patient who suddenly died from Chagas cardiomyopathy.

In the chronic digestive form of the disease, the clinical manifestations result from dysperistalsis of the esophagus and colon caused by destruction of the myenteric plexuses, which consequently leads to megaesophagus and megacolon. Although isolated cases of autonomic disorders of the esophagus have been described in the acute phase of the disease, these occur mostly in the chronic phase, when the dysperistalsis and spasms are accompanied by enlargement of the esophagus. This picture shows megacolon.

Enormous megacolon in patient who suddenly died from Chagas cardiomyopathy.